Duke-Margolis white paper examines methodologies for leveraging real-world evidence to support causal inference

The Duke-Margolis Institute for Health Policy has released a comprehensive white paper detailing the critical role of real-world evidence (RWE) in supporting causal inference in non-interventional studies. This paper, titled "Real-World Evidence to Support Causal Inference: Methodological Considerations for Non-Interventional Studies," explores the potential and challenges of utilizing RWE to complement traditional randomized controlled trials (RCTs). It underscores that establishing the credibility of RWE for causal inference – crucial for advancing evidence-based health care – requires robust study design, fit-for-purpose real-world data (RWD), clear communication, and rigorous statistical analysis. They emphasize the need for increased transparency in the reporting of...